NOVEL N-SUBSTITUTED -1H-ISOINDOLE-1,3(2H)DIONES OF POSSIBLE GENOTOXIC AND ANTICANCER ACTIVITIES

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

Several N-(heterocyclic)-1H-isoindole, were prepared from hydrazine carboxylic acid-1,3-dioxo-1,3-dihydro-isoindole-2-yl ester for the purpose of possible genotoxic activity against cancer cell line of mouse spleen.In conclusion, the correlation between chromosomal aberrations induction, suppression of proliferation rate and antitumour activity observed in this study, appeared to further substantiate the validity of the chromosomal aberration assay as a possible method for improving and guiding chemotherapy.

7 , 1 , 2017