Since ancient times, mankind all over the world mainly depended upon the plant kingdom to meet their all needs in medicines, for alleviating illness. The present study had been carried out to evaluate "invitro antihelminthic activity, phytochemical screening of regional medicinal plants used in state festival of telangana"(Bathukamma)" scientifically named celosia cristata'(amaranthaceae). The present study revealed that result of methanolic extract of celosia cristata (MECC) contains phytochemicals constituents like flavonoids, glycosides, carbohydrates, phenols, tannins, alkaloids etc. Compounds by phytochemical investigation with respect to chemical tests and paper chromatographic techniques. The aqueous extract of flowers showed paraylsis and death of earth worms more than standard drug piperazine citrate at both the lowest concentration of 25mg/ml and highest concentration of 100mg/ml, it might be due to presence of remarkable proved antihelminthics, glycosides, flavonoids and sterols present in the extract