124DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL ?- CARBOLINE DERIVATIVESA series of 51 compounds [N-(substituted-benzylidene)-?-carboline-3-carbohydrazide derivatives (Barbosa et al., 2011)] having significant inhibitory activity against cancer cell lines was selected and the presented biological activity (in micromolar concentration) of those compounds were conveniently converted into Log (1/IC50) values (molar) for carrying out QSAR analysis against anti-cancer activities using Chemoffice Ultra version 7.0.1, from Cambridge software corporation. The values of related parameters of all the molecules were calculated after effective energy minimization through MM2, MOPAC force fields provided by Chem3D Ultra 7.0.1Peshkar@gmail.comResearch1312023QSAR, ?-Carboline, Drug Design, Anti-Cancer, Cell LinesVarun Madhu Peshkar,Om Prakash AgrawalRKDF College of Pharmacy Near Ruchi Life escape, Jatkhedi, Misrod, Bhopal, Madhya Pradesh-462026,RKDF College of Pharmacy Near Ruchi Life escape, Jatkhedi, Misrod, Bhopal, Madhya Pradesh-462026